William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza win Nobel Prize in Medicine 2019 for discovery of how cells sense and adapt to oxygen availability

William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza win Nobel Prize in Medicine 2019 for discovery of how cells sense and adapt to oxygen availability

William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza win Nobel Prize in Medicine 2019 for discovery of how cells sense and adapt to oxygen availability

Nobel Prize in Physiology or Medicine 2019: The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability."

They identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.

They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function. Their discoveries have also paved the way for promising new strategies to fight anemia, cancer and many other diseases.

The Nobel Prize in Physiology or Medicine 2019

1. William G. Kaelin Jr
2. Sir Peter J. Ratcliffe
3. Gregg L. Semenza

Nobel Prize in Physiology or Medicine 2019 Awarded to William G. Kaelin Jr

William G. Kaelin Jr

The Nobel Prize in Physiology or Medicine 2019

Born: 1957, New York, NY, USA

Affiliation at the time of the award: Harvard Medical School, Boston, MA, USA, Howard Hughes Medical Institute, Chevy Chase, MD, USA

Prize motivation: "for their discoveries of how cells sense and adapt to oxygen availability."

Prize share: ⅓

Nobel Prize in Physiology or Medicine 2019 Awarded to Sir Peter J. Ratcliffe

Sir Peter J. Ratcliffe

The Nobel Prize in Physiology or Medicine 2019

Born: 1954, Lancashire, United Kingdom

Affiliation at the time of the award: University of Oxford, Oxford, United Kingdom, Francis Crick Institute, London, United Kingdom

Prize motivation: "for their discoveries of how cells sense and adapt to oxygen availability."

Prize share: ⅓

Nobel Prize in Physiology or Medicine 2019 Awarded to Gregg L. Semenza

Gregg L. Semenza

The Nobel Prize in Physiology or Medicine 2019

Born: 1956, New York, NY, USA

Affiliation at the time of the award: Johns Hopkins University, Baltimore, MD, USA

Prize motivation: "for their discoveries of how cells sense and adapt to oxygen availability."

Prize share: ⅓